How often should a follow-up Pap test occur if atypical squamous cells are found without HPV infection?

When atypical squamous cells are found on a Pap test but there is no evidence of HPV infection, it is recommended to follow up with a Pap test every 12 months. This approach aligns with clinical guidelines that prioritize regular monitoring to ensure that any potential progression to more serious abnormalities is detected early.

In this scenario, the presence of atypical squamous cells necessitates careful observation, but the absence of HPV decreases the immediate concern, allowing for an annual follow-up rather than a more frequent schedule. This balance helps manage patient care effectively by minimizing unnecessary interventions while ensuring suitable surveillance. Regular annual Pap tests in this context help to confirm whether the atypical changes are persistent or resolving, guiding future management decisions.