In the context of depression, which of the following indicates a need for routine laboratory tests?

In the context of assessing depression, laboratory tests can be vital for ruling out or identifying underlying medical conditions that may mimic or contribute to depressive symptoms. The indication for routine laboratory tests is strongly suggested by specific findings from the patient's history and physical examination.

When a clinician identifies particular signs or symptoms—such as significant weight loss, changes in appetite, fatigue, or any physical health issues that could correlate with depression—these findings can warrant laboratory testing. Tests may include measuring thyroid function or electrolyte levels, as conditions like hypothyroidism or electrolyte imbalances can lead to or worsen depressive symptoms.

Issues such as anxiety symptoms, failure to respond to treatment, or a family history of mood disorders do not inherently necessitate laboratory tests on their own. While all these factors can play a role in the overall management of depression, the direct link between specific clinical findings and the decision to conduct laboratory tests highlights the importance of thorough clinical assessment in this context.