What is a common side effect of mirtazapine, an antidepressant?

Mirtazapine is known for its sedative properties and its impact on appetite and weight. One of the most notable common side effects of mirtazapine is weight gain. This effect is primarily due to its action on the central nervous system, which can lead to increased appetite and a preference for carbohydrate-rich foods. The medication blocks certain receptors that, when activated, typically suppress appetite; thus, by blocking these receptors, mirtazapine leads to increased appetite and consequent weight gain in many individuals.

In clinical practice, this side effect can be significant, especially for patients who might already be predisposed to weight changes or those who have concerns about their body weight. This is also a distinguishing characteristic of mirtazapine compared to other antidepressants, which may lead to weight loss or have little effect on appetite. Understanding this side effect is vital for managing patient expectations and potential lifestyle impacts when prescribing this medication.