What is the best time to start treatment for herpes labialis?

Starting treatment for herpes labialis during the prodrome is optimal because this phase encompasses the initial symptoms that occur before the appearance of visible lesions. The prodromal phase typically includes sensations such as tingling, itching, or burning around the affected area, which serve as warning signs that an outbreak is imminent. Initiating antiviral therapy at this stage can significantly reduce the severity and duration of the outbreak, as the virus is more susceptible to treatment before the lesions develop.

Treating at the first sign of fever or during severe symptoms may not be as effective since the virus is already more established in the body. Waiting until after rash resolution means that the opportunity for early intervention has passed, which can lead to a longer healing time and increased discomfort. Therefore, beginning treatment during the prodromal phase is the best strategy to mitigate the impact of herpes labialis.