What is the first-line treatment for herpes labialis?

The first-line treatment for herpes labialis, which commonly presents as cold sores or fever blisters around the lips, is oral acyclovir. This antiviral medication is specifically designed to inhibit the replication of the herpes simplex virus (HSV). Acyclovir can significantly reduce the duration and severity of symptoms when administered during the prodromal phase or at the onset of an outbreak.

The effectiveness of oral acyclovir has been well-documented in clinical studies, showing that it can lead to quicker healing and relief from discomfort associated with herpes labialis. Additionally, for recurrent or severe cases, this antiviral may be taken as a daily suppressive therapy to decrease the frequency of outbreaks.

Topical analgesics may provide symptomatic relief but do not address the underlying viral infection, making them insufficient as a primary treatment. Invasive procedures are generally not indicated for herpes labialis because they do not effectively manage the viral infection. Natural remedies, while popular among some individuals, lack the robust clinical evidence necessary to establish them as a reliable treatment option. Therefore, oral acyclovir stands out as the most effective and appropriate first-line treatment for this condition.